Everyone knows the names of the major COVID variants Alpha, Delta, and Omicron. But last year, viral evolution shifted, muddying the waters, and the names of the major variants. Instead of spawning new variants, COVID began evolving within Omicron itselfat a breakneck pace, no less. The organization responsible for figuring out what to call the latest variants of concernthe World Health Organizationstopped using Greek letters after Omicron, arguing that all the new variants werent different enough to warrant nicknames.
Do you remember the previously ubiquitous COVID strains BA.4, BA.5, or BQ.1.1? Have you heard of the currently surging XBB.1.5, and do you understand what the tangle of letters and numbers mean? You probably dontand some experts say its because of the names. You could be forgiven for thinking another strain of Omicron poses no new threatespecially if youve already had Omicron or received the new Omicron booster.
New strains of Omicron are becoming increasingly more transmissible and evasive, with the ability to dodge immunity from prior vaccination and infection. And using the term Omicron or something like XBB.1.5 to describe them just isnt cutting it anymore, Dr. Ryan Gregory, a biology professor at the University of Guelph in Ontario, Canada, told Fortune.
Kraken is what he calls XBB.1.5, which the WHO just declared the most transmissible Omicron variant yet. For months, Gregory has worked to offer up street names for complicated COVID strains, in a bid to better communicate the evolving Omicron threat to the public.
And as pseudonyms go, hes got a lot more where the kraken came from.
With input from both professional and citizen scientists around the globe, Gregory has compiled a list of memorable monikers from Greek mythology and other realms Chiron, Argus, Basilisk, and Typhonfor the Omicron spawn that medical experts believe pose the greatest threat in the near future. He told Fortune he was inspired by a Twitter user who dubbed the Omicron strain BA.2.75 Centaurus this summer, and saw the media and some experts pick that up.
Since Gregory began using Krakenan aggressive sea monster from Scandinavian folkloreshortly after Christmas, its quickly gained steam, as reported by Bloomberg. The term has been picked up by a host of other international and national news outlets including Insider and Sky News. Centaurus was named in journal articles and used by the likes of Nature and The Guardian. And some variant trackers are now using the proposed names as hashtags on Twitter.
Gregory likened Omicron and its variants to different species within the mammal family of vertebrates.
If you said, Oh, whats that thing in my yard? and I said, Its a mammal, Youd say, Is it something that will eat me? Will it steal my vegetables? Does it carry disease? Is it somebodys pet? he explained.
Omicron remains a useful descriptor, he maintained. But more than a year after the highly transmissible Omicron strain burst onto the global scene, someone needs to name new, concerning variants.
If the WHO wont, hes decided that he will.
Gone are the days of Greek letters?
When COVID variants began materializing, the WHO devised the strategy of naming them after Greek letters, skipping some that might be confusinglike Nu, which sounds like new, which would apply to all variants at some pointor offensive to some, like Xi, the first name of Chinas president.
Generally, the approach worked, Gregory said. But Omicron muddled matters.
Dr. Raj Rajnarayanan, assistant dean of research and associate professor at the New York Institute of Technology campus in Jonesboro, Ark., is on Gregorys informal team to develop nicknames for particularly troublesome Omicron spin-offs.
Even as a seasoned scientist and professor, Rajnarayanan said hes found it difficult to effectively communicate with non-scientists regarding the tangled mess of variants scientists are monitoring.
When you keep calling 200 different lineages of different potential the same name, it becomes a problem, he recently told Fortune.
Experts like Gregory and Rajnarayanan worry that a lack of a new and specific names for Omicron variants could lead members of the public to draw false conclusionslike that the virus isnt evolving, or that infection with Omicron months ago will confer protection against newer strains of Omicron, which isnt necessarily true.
The public cant keep these numbers straight
So far, the WHO has declined to give particularly concerning Omicron variants a Greek letter. Fortune reached out to the international health organization to ask why and didnt receive a response.
Its resistance is based in science, since new Omicron variants can be traced back to older Omicron variants. But its not practical, Dr. Eric Topol, a professor of molecular medicine at Scripps Research and founder and director of the Scripps Research Translational Institute, told Fortune last fall.
And its not a good defense for not naming them, he added. I would implore them to do so. The public cant keep these numbers straight.
Topol says he would have called BA.5, dominant globally until recently, Pi or Sigma because its so distinct from the original Omicron, BA.1, as well as the so-called stealth Omicron, or BA.2.
Two particularly worrying recent variantsBQ.1.1 and XBBshould also be assigned Greek letters because researchers have called them extreme in terms of immune-evasiveness and resistance to monoclonal antibodies, he said at the time.
They could be given new Greek letter names instead of the ones some people invent, he said of the new strains. If different people are going to make up names, its going to be just as confusing as the numbers or letters.
Basilisk here, Hydra there
When describing potentially threatening variants, the WHO currently uses so-called Pango lineagescombinations of letters and numbers youve likely heard of, like BA.2.75.2 and BA.4.6.
Pango labels have maintained their specificity as the virus mutates unrestrained, Gregory said. But such labels are almost too precise for the general public. And aside from being forgettable, theyre easily confused.
When I talk to people, I say BA.1, and they think Im saying BL.1and thats a different variant, Rajnarayanan said. Even the two-letter system causes confusion.
Gregory equates Pango names to technical species names, like Mus musculus for muscle or Rattus norvegicus for rat. Such technical names arent often used by the general public. Some species of animals, howeverlike Oncorhynchus mykiss, or rainbow troutget a common name because we encounter them a lot, theyre important to us, theyre dangerous or useful or delicious or whatever, he said.
And so it should be with COVID variants, he contends. Particularly rampant, high-flying variants like XBB, a blend of BJ.1 and BM.1.1.1, should get a nicknameGryphon, per his systemfor ease of communicating the threat to the general public.
Its especially important, he says, as a menagerie of Omicron spawn spike in different locations around the world in a fashion unlike any seen in the pandemic so far.
If we want to make it clear that whats rising in the U.K. is not the same as whats rising in the U.S.the alphabet soup is going to be very difficult for that, he said. Hes convinced that if his system was adopted, with, say Basilisk and Cerberus in the U.K., and Hydra and Aeterna in the U.S., you can immediately recognize which names are the same and which are not.
If COVID keeps spawning new mutations, there are other lists of names to tapplanets, stars, constellations, galaxies, Gregory said.
What in the world will he think of next?
